RUNX represses Pmp22 to drive neurofibromagenesis
نویسندگان
چکیده
منابع مشابه
Addiction to RUNX in lymphoma
Runx genes encode transcription factors that play essential but distinct and lineage-specific roles in development. These sequence-specific DNA binding proteins share a common binding cofactor (CBFβ) that confers protein stability and high affinity for target DNA on its RUNX partners. An important link to cancer was first realised through identification of both RUNX1 and CBFB as frequent target...
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The Runt-related transcription factor-1 (RUNX1 or AML1) encodes a transcription factor that serves as a master developmental regulator. It is important for hematopoiesis, angiogenesis, maturation of megakaryocytes, and differentiation of T and B cells [1]. Runx1 is also important for neuronal development and glial cell differentiation [2]. Runx1 is integrated into a complex regulatory network w...
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The three mammalian RUNX genes have evolved distinctive and highly lineage-specific roles in development but show evidence of redundant functions in oncogenesis where they may function either as oncogenes or tumor suppressors according to context [1]. The core binding complexes formed by RUNX proteins and their cofactor CBFB accomplish their essential roles by activating or repressing target ge...
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Anuradha Illendula , Jane Gilmour , Jolanta Grembecka , Venkata Sesha Srimath Tirumala , Adam Boulton , Aravinda Kuntimaddi , Charles Schmidt , Lixin Wang , John A. Pulikkan , Hongliang Zong , Mahmut Parlak , Cem Kuscu , Anna Pickin , Yunpeng Zhou , Yan Gao , Lauren Mishra , Mazhar Adli , Lucio H. Castilla , Roger A. Rajewski , Kevin A. Janes , Monica L. Guzman , Constanze Bonifer , John H. Bus...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2019
ISSN: 2375-2548
DOI: 10.1126/sciadv.aau8389